Drawing upon the latest breakthrough in skin science, CosmoDerm and CosmoPlast are made from natural human collagen grown under controlled laboratory conditions. This human collagen is similar to the collagen normally found in the skin.

There is no need for a pre-treatment skin test, which means CosmoDerm and CosmoPlast offer physicians and patients the convenience of Collagen Replacement Therapy in just one office visit.

  • The first FDA-approved dermal fillers to not require a skin test

  • Immediate results with no down time

  • Formulated with lidocaine for patient comfort

  • Screened multiple times to ensure purity

  • Complement to Botulinum Toxin treatments

  • Have been used with hyaluronic acid-based dermal fillers. The safety and effectiveness of combination use has not been clinically evaluated however.


CosmoDerm and CosmoPlast collagen-based dermal fillers are sterile devices composed of highly purified human-based collagen that is dispersed in phosphate-buffered physiological saline containing 0.3% lidocaine. CosmoDerm is a non-cross-linked formulation used in the treatment of superficial lines, whereas CosmoPlast is cross-linked and is primarily used in the treatment of more pronounced wrinkles.

  • CosmoDerm 1 - Purified human-based collagen 35 mg/mL, dispersed in saline. Indicated to treat fine lines, wrinkles and shallow scars. For thin-skinned areas. No skin test required.

  • CosmoPlast - Purified human-based collagen 35 mg/mL, cross-linked with glutaraldehyde dispersed in saline. Indicated to treat deep lines, furrows and scars. No skin test required.

Packaged as 6 single-use-only disposable syringes ready for use.

For additional treatment options, please review our product information on Hylaform® a new hyaluronic acid-based filler and the latest dermal filler to be approved by the FDA. And Zyderm® and Zyplast® collagen, used safely and effectively for more than 20 years.

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